How Can We Help?
You are here:
< Back
Chemical compound
Zetekitoxin AB (ZTX) is a guanidine alkaloid found in the Panamanian golden frog Atelopus zeteki. It is an extremely potent neurotoxin.
Structure
ZTX is a guanidine alkaloid. It's structurally related to saxitoxin, but with some differences. ZTX has a guanidine core similar to saxitoxin. It contains an isoxazolidine ring, a sulfonate group and a N-hydroxycarbamate group.[2]
Mechanism of action
ZTX is an extremely potent sodium channel blocker. It has been shown to block the voltage-gated sodium channels at picomolar concentrations. It is about 580 times more potent than saxitoxin.[2]
Toxicity
ZTX is an extremely potent neurotoxin. The LD50 of ZTX in mice is 11 μg/kg.[3]
See also
References
- ^ Chambers, Michael. "ChemIDplus - 0062996387 - Zetekitoxin AB - Searchable synonyms, formulas, resource links, and other chemical information". chem.nlm.nih.gov.
- ^ a b Yotsu-Yamashita, M.; Kim, Y. H.; Dudley, S. C.; Choudhary, G.; Pfahnl, A.; Oshima, Y.; Daly, J. W. (22 March 2004). "The structure of zetekitoxin AB, a saxitoxin analog from the Panamanian golden frog Atelopus zeteki: A potent sodium-channel blocker". Proceedings of the National Academy of Sciences. 101 (13): 4346–4351. Bibcode:2004PNAS..101.4346Y. doi:10.1073/pnas.0400368101. PMC 384749. PMID 15070720.
- ^ Brown, George B.; Kim, Yong H.; Küntzel, Heiner; Mosher, Harry S.; Fuhrman, Geraldine J.; Fuhrman, Frederick A. (January 1977). "Chemistry and pharmacology of skin toxins from the frog Atelopus Zeteki (Atelopidtoxin: Zetekitoxin)". Toxicon. 15 (2): 115–128. doi:10.1016/0041-0101(77)90030-7. PMID 558664.
Animal toxins | |
---|---|
Bacterial | |
Cyanotoxins | |
Plant toxins | |
Mycotoxins | |
Pesticides | |
Nerve agents | |
Bicyclic phosphates | |
Other |
Calcium |
| ||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Potassium |
| ||||||||||||||||||||||||
Sodium |
| ||||||||||||||||||||||||
Chloride |
| ||||||||||||||||||||||||
Others |
| ||||||||||||||||||||||||
Categories
-
Annuals36
-
Bulbs, Corms & Tubers41
-
Ferns27
-
Fruits3
-
Garden Plants23
-
Grasses26
-
Herb17
-
Insects1
-
Mammals1
-
Midwest Native Plants0
-
Northeast Native Plants112
-
Perennials123
-
Rose1
-
Shrubs47
-
Trees112
-
Tropical Plants53
-
Upland Birds5
-
Vines18
-
Viola Tricolor1
-
Water Gardening & Plants9
-
Waterfowl0
-
Wetland Birds0
-
Wetland Plants4
-
Wildbirds172
-
Wildflowers1
-
Woodland Plants29
Table of Contents
Recent Comments