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VANGL planar cell polarity protein 2 is a protein that in humans is encoded by the VANGL2 gene. [5]
Function
The protein encoded by the VANGL2 gene is a membrane protein involved in the regulation of planar cell polarity, especially in the stereociliary bundles of the cochlea. The encoded protein transmits directional signals to individual cells or groups of cells in epithelial sheets. This protein is also involved in the development of the neural plate. [provided by RefSeq, Sep 2011].
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000162738 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026556 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: VANGL planar cell polarity protein 2". Retrieved 2018-07-05.
Further reading
- Erdal E, Erdal C, Bulut G, Kunter I, Kir M, Atabey N, Açikel U (2007). "Mutation analysis of the Vangl2 coding region revealed no common cause for Tetralogy of Fallot". J. Int. Med. Res. 35 (6): 867–72. doi:10.1177/147323000703500614. PMID 18034999. S2CID 28747920.
- Cantrell VA, Jessen JR (January 2010). "The planar cell polarity protein Van Gogh-Like 2 regulates tumor cell migration and matrix metalloproteinase-dependent invasion". Cancer Lett. 287 (1): 54–61. doi:10.1016/j.canlet.2009.05.041. PMID 19577357.
- Yates LL, Schnatwinkel C, Murdoch JN, Bogani D, Formstone CJ, Townsend S, Greenfield A, Niswander LA, Dean CH (June 2010). "The PCP genes Celsr1 and Vangl2 are required for normal lung branching morphogenesis". Hum. Mol. Genet. 19 (11): 2251–67. doi:10.1093/hmg/ddq104. PMC 2865378. PMID 20223754.
- Lei YP, Zhang T, Li H, Wu BL, Jin L, Wang HY (June 2010). "VANGL2 mutations in human cranial neural-tube defects". N. Engl. J. Med. 362 (23): 2232–5. doi:10.1056/NEJMc0910820. PMID 20558380.
- Lei YP, Zhang T, Li H, Wu BL, Jin L, Wang HY (June 2010). "VANGL2 mutations in human cranial neural-tube defects". N. Engl. J. Med. 362 (23): 2232–5. doi:10.1056/NEJMc0910820. PMID 20558380.
- Kibar Z, Salem S, Bosoi CM, Pauwels E, De Marco P, Merello E, Bassuk AG, Capra V, Gros P (July 2011). "Contribution of VANGL2 mutations to isolated neural tube defects". Clin. Genet. 80 (1): 76–82. doi:10.1111/j.1399-0004.2010.01515.x. PMC 3000889. PMID 20738329.
- Iliescu A, Gravel M, Horth C, Kibar Z, Gros P (February 2011). "Loss of membrane targeting of Vangl proteins causes neural tube defects". Biochemistry. 50 (5): 795–804. doi:10.1021/bi101286d. PMID 21142127.
- Guo Y, Zanetti G, Schekman R (January 2013). "A novel GTP-binding protein-adaptor protein complex responsible for export of Vangl2 from the trans Golgi network". eLife. 2: e00160. doi:10.7554/eLife.00160. PMC 3539332. PMID 23326640.
- Piazzi G, Selgrad M, Garcia M, Ceccarelli C, Fini L, Bianchi P, Laghi L, D'Angelo L, Paterini P, Malfertheiner P, Chieco P, Boland CR, Bazzoli F, Ricciardiello L (April 2013). "Van-Gogh-like 2 antagonises the canonical WNT pathway and is methylated in colorectal cancers". Br. J. Cancer. 108 (8): 1750–6. doi:10.1038/bjc.2013.142. PMC 3668461. PMID 23579212.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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