Trazpiroben (developmental code name TAK-906) is a dopamine antagonist drug which was under development for the treatment of gastroparesis.[1][2][3][4][5] It acts as a peripherally selective dopamine D2 and D3 receptor antagonist.[1][2] The drug has been found to strongly increase prolactin levels in humans, similarly to other peripherally selective D2 receptor antagonists like domperidone.[5] Clinical development of trazpiroben was discontinued before April 2022.[1] Trazpiroben was originated by Altos Therapeutics and was under development by Takeda Oncology.[1]

References

  1. ^ a b c d "Trazpiroben - Takeda Oncology - AdisInsight".
  2. ^ a b Whiting RL, Choppin A, Luehr G, Jasper JR (October 2021). "Preclinical Evaluation of the Effects of Trazpiroben (TAK-906), a Novel, Potent Dopamine D2/D3 Receptor Antagonist for the Management of Gastroparesis". J Pharmacol Exp Ther. 379 (1): 85–95. doi:10.1124/jpet.121.000698. PMID 34253646. S2CID 235809216.
  3. ^ Whiting RL, Darpo B, Chen C, Fletcher M, Combs D, Xue H, Stoltz RR (August 2021). "Safety, Pharmacokinetics, and Pharmacodynamics of Trazpiroben (TAK-906), a Novel Selective D2 /D3 Receptor Antagonist: A Phase 1 Randomized, Placebo-Controlled Single- and Multiple-Dose Escalation Study in Healthy Participants". Clin Pharmacol Drug Dev. 10 (8): 927–939. doi:10.1002/cpdd.906. PMC 8451790. PMID 33462988.
  4. ^ Kuo B, Scimia C, Dukes G, Zhang W, Gupta S, Chen C, Chuang E, Camilleri M (August 2021). "Randomised clinical trial: safety, pharmacokinetics and pharmacodynamics of trazpiroben (TAK-906), a dopamine D2 /D3 receptor antagonist, in patients with gastroparesis". Aliment Pharmacol Ther. 54 (3): 267–280. doi:10.1111/apt.16451. PMID 34148244. S2CID 235492049.
  5. ^ a b Yamaguchi T, Kudou K, Okamoto H, Chen C, Whiting R, Sekino H (December 2021). "Evaluating the Safety, Tolerability, and Disposition of Trazpiroben, a D2 /D3 Receptor Antagonist: Phase I Single- and Multiple-Ascending Dose Studies in Healthy Japanese Participants". Clin Pharmacol Drug Dev. 11 (6): 695–706. doi:10.1002/cpdd.1057. PMC 9303893. PMID 34967147. S2CID 245567576.

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