Thiopropazate (Artalan, Dartal, Dartalan, Dartan) is a typical antipsychotic of the phenothiazine class.[1] It is a prodrug to perphenazine.

Thiopropazate is manufactured by Searle (US, UK) & Boehringer Mannheim (Germany)[2] Thiopropazate is sold by Chembase, AAA Chemistry, ZINC, AKos Consulting & Solutions, Boc Sciences, ChemFrog, and ChemMol[3]

Synthesis

Thieme Patent:[4]

The alkylation of 2-chloro-10-(3-chloropropyl)phenothiazine [2765-59-5] (1) with Piperazine (2) gives N-Desmethylprochlorperazine [40323-85-1] (3). Further alkylation with 2-Bromoethyl acetate [927-68-4] (4) gives Thiopropazate (5).

See also

References

  1. ^ Buckingham J (1996). Dictionary of organic compounds. London: Chapman & Hall. p. 5148. ISBN 0-412-54090-8.
  2. ^ Pharmaceutical Manufacturing Encyclopedia p. 3209
  3. ^ "Thiopropazate". PubChem. United States Library of Medicine.
  4. ^ John W Cusic, U.S. patent 2,766,235 (1956 to Searle & Co).