Tangeretin is an O-polymethoxylated flavone that is found in tangerine and other citrus peels. Tangeretin strengthens the cell wall and acts as a plant's defensive mechanism against disease-causing pathogens.[2]

It has also been used as a marker compound to detect contamination in citrus juices.[2]

The following is a list of methods used to extract tangeretin from citrus peels:

  • column chromatography
  • preparative-high performance liquid chromatography
  • super critical fluid chromatography
  • high speed counter current chromatography
  • a combination of vacuum flash silica gel chromatography and flash C8 column chromatography
  • flash chromatography
  • isolation using ionic liquids and a cycle of centrifugation and decantation[3]

The low solubility of Tangeretin is one of the main reasons for the low bioavailability of Tangeretin (and other flavonoids in general), and has been reported as a major challenge when using the compound in laboratory procedures.[4] However, methods for tangeretin extraction are currently being tested to maximize efficiency and percent yields as its uses in treatment of cancer and other diseases are becoming better understood.[2]

Tangeretin is commercially available as a dietary supplement. Tangeretin has also demonstrated beneficial applications in other pharmaceutical, nutraceutical, and cosmetic processes.[4]

Tangeretin can be found as various synonyms throughout literature and research, including Tangeritin and 5,6,7,8,4’-pentamethoxyflavone (VIII).[3]

References

  1. ^ a b c SciFinder.com (accessed Nov. 6, 2012). Tangeretin (481-53-8).
  2. ^ a b c Uckoo, RM; et al. Sep. Purif. Technol. 2011.
  3. ^ a b Mizuno, H.; Yoshikawa, H.; Usuki, T. Extraction of Nobiletin and Tangeretin From Peels of Shekwasha and Ponkan Using [C2mim][(MeO)(H)PO2] and Centrifugation. Natural Product Communications 2019, 14, 1-6.
  4. ^ a b Panche, A. N.; Diwan, A. D.; Chandra, S. R. Flavonoids: an overview. Journal of Nutritional Science. 2016, 5, 47.