TCS 1205 is an organic chemical compound. It is a benzodiazepine site agonist selective for certain sub-units.

Pharmacology

TCS 1205 acts at the benzodiazepine binding site, it is selective for the a1 and a2 subunits of the GABAA receptor.[1] In vivo, it has anxiolytic effects but no sedative effects.[2][3]

Chemistry

Despite acting at the benzodiazepine receptor, it does not contain the benzodiazepine structure, it could therefore be classed as a Nonbenzodiazepine.

References

  1. ^ https://documents.tocris.com/pdfs/tocris_coa/3941_1_coa.pdf?1706728634
  2. ^ "TCS 1205 | CAS 355022-97-8 | AbMole BioScience | TCS 1205 Price".
  3. ^ Taliani, Sabrina; Cosimelli, Barbara; Da Settimo, Federico; Marini, Anna Maria; La Motta, Concettina; Simorini, Francesca; Salerno, Silvia; Novellino, Ettore; Greco, Giovanni; Cosconati, Sandro; Marinelli, Luciana; Salvetti, Francesca; L’Abbate, Gianluca; Trasciatti, Silvia; Montali, Marina; Costa, Barbara; Martini, Claudia (25 June 2009). "Identification of Anxiolytic/Nonsedative Agents among Indol-3-ylglyoxylamides Acting as Functionally Selective Agonists at the γ-Aminobutyric Acid-A (GABA A ) α 2 Benzodiazepine Receptor". Journal of Medicinal Chemistry. 52 (12): 3723–3734. doi:10.1021/jm9001154.