Sulfadoxine (also spelled sulphadoxine) is an ultra-long-lasting sulfonamide used in combination with pyrimethamine to treat malaria.[1]

It is also used to prevent malaria[2] but due to high levels of sulphadoxine-pyrimethamine resistance, this use has become less common.[3]

It is also used, usually in combination with other drugs, to treat or prevent various infections in livestock.[citation needed]

Mechanism of action

Sulfadoxine competitively inhibits dihydropteroate synthase, interfering with folate synthesis.[citation needed]

See also

References

Scholia has a topic profile for Sulfadoxine.
  1. ^ Medical Treatment - Sulphadoxine and Pyrimethamine Archived 2007-12-28 at the Wayback Machine.
  2. ^ "WHO | Intermittent preventive treatment in pregnancy (IPTp)". Who.int. Archived from the original on March 5, 2014. Retrieved 27 November 2021.
  3. ^ Matondo SI, Temba GS, Kavishe AA, et al. (2014). "High levels of sulphadoxine-pyrimethamine resistance Pfdhfr-Pfdhps quintuple mutations: a cross sectional survey of six regions in Tanzania". Malar J. 13: 152. doi:10.1186/1475-2875-13-152. PMC 3998221. PMID 24751352.