Solute carrier organic anion transporter family member 4C1 is a protein that in humans is encoded by the SLCO4C1 gene, which is located on chromosome 5q21. The OATP4C1 protein is expressed in the basolateral membrane of the nephron of the human kidney, where it is involved in the uptake of organic anions for elimination in the urine. The drug digoxin is an important substrate of this transporter.[5][6]

Function

SLCO4C1 belongs to the organic anion transporter (OATP) family. OATPs are involved in the membrane transport of bile acids, conjugated steroids, thyroid hormone, eicosanoids, peptides, and numerous drugs in many tissues (Mikkaichi et al., 2004 [PubMed 14993604]).

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000173930 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040693 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Mikkaichi T, Suzuki T, Onogawa T, et al. (March 2004). "Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney". Proc. Natl. Acad. Sci. U.S.A. 101 (10): 3569–74. Bibcode:2004PNAS..101.3569M. doi:10.1073/pnas.0304987101. PMC 373503. PMID 14993604.
  6. ^ "Entrez Gene: Solute carrier organic anion transporter family member 4C1". Retrieved 2016-03-11.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.