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Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 is an enzyme that in humans is encoded by the ST6GALNAC1 gene.[5] This enzyme adds a N-Acetylneuraminic acid (Sialic Acid/Neu5Ac) to an O-linked N-Acetylgalactosamine (GalNAc) on a peptide/proteins (also called Tn antigen) with an α2-6 linkage to produce the sialyl-Tn antigen. It has been shown that the enzyme prefers Thr over Ser containing GalNAc residues.[6][7]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000070526 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000009588 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: ST6GALNAC1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1".
- ^ Mehta AY, Veeraiah RK, Dutta S, Goth CK, Hanes MS, Gao C, et al. (June 2020). "Parallel Glyco-SPOT Synthesis of Glycopeptide Libraries". Cell Chemical Biology. 27 (9): 1207–1219.e9. doi:10.1016/j.chembiol.2020.06.007. PMC 7556346. PMID 32610041.
- ^ Yoshimura Y, Denda-Nagai K, Takahashi Y, Nagashima I, Shimizu H, Kishimoto T, et al. (November 2019). "Products of Chemoenzymatic Synthesis Representing MUC1 Tandem Repeat Unit with T-, ST- or STn-antigen Revealed Distinct Specificities of Anti-MUC1 Antibodies". Scientific Reports. 9 (1): 16641. Bibcode:2019NatSR...916641Y. doi:10.1038/s41598-019-53052-1. PMC 6851390. PMID 31719620.
Further reading
- Lee YC, Kaufmann M, Kitazume-Kawaguchi S, Kono M, Takashima S, Kurosawa N, Liu H, Pircher H, Tsuji S (April 1999). "Molecular cloning and functional expression of two members of mouse NeuAcalpha2,3Galbeta1,3GalNAc GalNAcalpha2,6-sialyltransferase family, ST6GalNAc III and IV". The Journal of Biological Chemistry. 274 (17): 11958–67. doi:10.1074/jbc.274.17.11958. PMID 10207017.
- Ikehara Y, Kojima N, Kurosawa N, Kudo T, Kono M, Nishihara S, Issiki S, Morozumi K, Itzkowitz S, Tsuda T, Nishimura SI, Tsuji S, Narimatsu H (November 1999). "Cloning and expression of a human gene encoding an N-acetylgalactosamine-alpha2,6-sialyltransferase (ST6GalNAc I): a candidate for synthesis of cancer-associated sialyl-Tn antigens". Glycobiology. 9 (11): 1213–24. doi:10.1093/glycob/9.11.1213. PMID 10536037.
- Donadio S, Dubois C, Fichant G, Roybon L, Guillemot JC, Breton C, Ronin C (2004). "Recognition of cell surface acceptors by two human alpha-2,6-sialyltransferases produced in CHO cells". Biochimie. 85 (3–4): 311–21. doi:10.1016/S0300-9084(03)00080-4. PMID 12770770.
- Julien S, Krzewinski-Recchi MA, Harduin-Lepers A, Gouyer V, Huet G, Le Bourhis X, Delannoy P (2003). "Expression of sialyl-Tn antigen in breast cancer cells transfected with the human CMP-Neu5Ac: GalNAc alpha2,6-sialyltransferase (ST6GalNac I) cDNA". Glycoconjugate Journal. 18 (11–12): 883–93. doi:10.1023/A:1022200525695. PMID 12820722. S2CID 21051703.
- Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (October 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
- Sewell R, Bäckström M, Dalziel M, Gschmeissner S, Karlsson H, Noll T, Gätgens J, Clausen H, Hansson GC, Burchell J, Taylor-Papadimitriou J (February 2006). "The ST6GalNAc-I sialyltransferase localizes throughout the Golgi and is responsible for the synthesis of the tumor-associated sialyl-Tn O-glycan in human breast cancer". The Journal of Biological Chemistry. 281 (6): 3586–94. doi:10.1074/jbc.M511826200. PMID 16319059.
- Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
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