Hosta

Sclerostin domain-containing protein 1 is a protein that in humans is encoded by the SOSTDC1 gene.^[5]

Function

This gene is a member of the sclerostin family and encodes Uterine sensitization-associated gene-1 (USAG-1), an N-glycosylated, secreted protein with a C-terminal, cystine, knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during cellular proliferation, differentiation, and programmed cell death.^[5]

Inhibition of USAG-1 is of interest as a potential means of stimulating tooth regrowth for dentistry.^[6]^[7]^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000171243 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036169 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: SOSTDC1 sclerostin domain containing 1".
^ Murashima-Suginami A, Kiso H, Tokita Y, Mihara E, Nambu Y, Uozumi R, Tabata Y, Bessho K, Takagi J, Sugai M, Takahashi K (February 2021). "Anti-USAG-1 therapy for tooth regeneration through enhanced BMP signaling". Science Advances. 7 (7). doi:10.1126/sciadv.abf1798. PMC 7880588. PMID 33579703.
^ Ravi V, Murashima-Suginami A, Kiso H, Tokita Y, Huang CL, Bessho K, Takagi J, Sugai M, Tabata Y, Takahashi K (March 2023). "Advances in tooth agenesis and tooth regeneration". Regenerative Therapy. 22: 160–168. doi:10.1016/j.reth.2023.01.004. PMC 9931762. PMID 36819612.
^ "World's 1st 'tooth regrowth' medicine moves toward clinical trials in Japan". Mainichi. 12 June 2023.

Yanagita M (June 2005). "BMP antagonists: their roles in development and involvement in pathophysiology". Cytokine & Growth Factor Reviews. 16 (3): 309–17. doi:10.1016/j.cytogfr.2005.02.007. PMID 15951218.
Laurikkala J, Kassai Y, Pakkasjärvi L, Thesleff I, Itoh N (December 2003). "Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot". Developmental Biology. 264 (1): 91–105. doi:10.1016/j.ydbio.2003.08.011. PMID 14623234.
Yanagita M, Oka M, Watabe T, Iguchi H, Niida A, Takahashi S, Akiyama T, Miyazono K, Yanagisawa M, Sakurai T (April 2004). "USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney". Biochemical and Biophysical Research Communications. 316 (2): 490–500. doi:10.1016/j.bbrc.2004.02.075. PMID 15020244.
Goto M, Eddy EM (October 2004). "Speriolin is a novel spermatogenic cell-specific centrosomal protein associated with the seventh WD motif of Cdc20". The Journal of Biological Chemistry. 279 (40): 42128–38. doi:10.1074/jbc.M403190200. PMID 15280373.