How Can We Help?
RAP1 GTPase activating protein 2 is a protein in humans that is encoded by the RAP1GAP2 gene.[5]
This gene encodes a GTPase-activating protein that activates the small guanine-nucleotide-binding protein Rap1 in platelets. The protein interacts with synaptotagmin-like protein 1 and Rab27 and regulates secretion of dense granules from platelets at sites of endothelial damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000132359 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038807 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: RAP1 GTPase activating protein 2".
Further reading
- Neumüller O, Hoffmeister M, Babica J, Prelle C, Gegenbauer K, Smolenski AP (August 2009). "Synaptotagmin-like protein 1 interacts with the GTPase-activating protein Rap1GAP2 and regulates dense granule secretion in platelets". Blood. 114 (7): 1396–404. doi:10.1182/blood-2008-05-155234. hdl:10197/5848. PMID 19528539. S2CID 24339637.
- Aouizerat BE, Vittinghoff E, Musone SL, Pawlikowska L, Kwok PY, Olgin JE, Tseng ZH (June 2011). "GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease". BMC Cardiovascular Disorders. 11: 29. doi:10.1186/1471-2261-11-29. PMC 3141757. PMID 21658281.
- Balduini A, Pecci A, Lova P, Arezzi N, Marseglia C, Bellora F, Perotti C, Balduini C, Balduini CL, Torti M (October 2004). "Expression, activation, and subcellular localization of the Rap1 GTPase in cord blood-derived human megakaryocytes". Experimental Cell Research. 300 (1): 84–93. doi:10.1016/j.yexcr.2004.07.011. PMID 15383317.
- Kimura T, Mogi C, Sato K, Tomura H, Ohta H, Im DS, Kuwabara A, Kurose H, Murakami M, Okajima F (October 2011). "p2y5/LPA(6) attenuates LPA(1)-mediated VE-cadherin translocation and cell-cell dissociation through G(12/13) protein-Src-Rap1". Cardiovascular Research. 92 (1): 149–58. doi:10.1093/cvr/cvr154. PMID 21632882.
- Schultess J, Danielewski O, Smolenski AP (April 2005). "Rap1GAP2 is a new GTPase-activating protein of Rap1 expressed in human platelets". Blood. 105 (8): 3185–92. doi:10.1182/blood-2004-09-3605. hdl:10197/5867. PMID 15632203.
- Hoffmeister M, Riha P, Neumüller O, Danielewski O, Schultess J, Smolenski AP (January 2008). "Cyclic nucleotide-dependent protein kinases inhibit binding of 14-3-3 to the GTPase-activating protein Rap1GAP2 in platelets" (PDF). The Journal of Biological Chemistry. 283 (4): 2297–306. doi:10.1074/jbc.M706825200. PMID 18039662. S2CID 20190382.
Recent Comments