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The capsid of SV40, an icosahedral virus
The capsid of SV40, an icosahedral virus

Viruses are small infectious agents that can replicate only inside the living cells of an organism. Viruses infect all forms of life, including animals, plants, fungi, bacteria and archaea. They are found in almost every ecosystem on Earth and are the most abundant type of biological entity, with millions of different types, although only about 6,000 viruses have been described in detail. Some viruses cause disease in humans, and others are responsible for economically important diseases of livestock and crops.

Virus particles (known as virions) consist of genetic material, which can be either DNA or RNA, wrapped in a protein coat called the capsid; some viruses also have an outer lipid envelope. The capsid can take simple helical or icosahedral forms, or more complex structures. The average virus is about 1/100 the size of the average bacterium, and most are too small to be seen directly with an optical microscope.

The origins of viruses are unclear: some may have evolved from plasmids, others from bacteria. Viruses are sometimes considered to be a life form, because they carry genetic material, reproduce and evolve through natural selection. However they lack key characteristics (such as cell structure) that are generally considered necessary to count as life. Because they possess some but not all such qualities, viruses have been described as "organisms at the edge of life".

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Symptoms of Ebola virus disease

Ebola virus disease is a viral haemorrhagic fever of humans and other primates caused by ebolaviruses, RNA viruses in the Filoviridae family. The natural host is thought to be megabats. The virus spreads by contact with body fluids, such as blood. After an incubation period of 2–21 days, nonspecific symptoms including fever, sore throat, muscle pain and headache develop, followed by vomiting, diarrhoea, rash, liver and kidney impairment, and sometimes internal or external bleeding. On average, around half of those infected die, often from hypovolaemic shock. The virus sometimes persists in semen or breast milk for several weeks or months after recovery.

The disease was first identified in 1976 by Peter Piot and others in two simultaneous outbreaks, one in Nzara, Sudan and the other in Yambuku, then in Zaire, near the Ebola River, for which the disease is named. Outbreaks have occurred intermittently in tropical regions of sub-Saharan Africa, with a few thousand cases documented before the epidemic in Western Africa of 2013–16, in which nearly 29,000 cases with more than 11,000 deaths were reported. More than 3000 cases were documented in a subsequent epidemic in the Democratic Republic of the Congo in 2018–20, with more than 2000 deaths. Prevention of outbreaks focuses on limiting virus transmission from infected animals to humans, for example, by taking precautions when handling bush meat. Ebola vaccines are now available. Monoclonal antibody treatments can improve outcomes, and a combination of three monoclonals has been licensed.

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Castor bean tick, Ixodes ricinus

The castor bean tick, Ixodes ricinus, can transmit the tick-borne encephalitis virus. Ticks are common vectors for viruses, and other tick-borne diseases include Colorado tick fever and Crimean–Congo haemorrhagic fever.

Credit: Richard Bartz (24 April 2009)

In the news

Map showing the prevalence of SARS-CoV-2 cases; black: highest prevalence; dark red to pink: decreasing prevalence; grey: no recorded cases or no data
Map showing the prevalence of SARS-CoV-2 cases; black: highest prevalence; dark red to pink: decreasing prevalence; grey: no recorded cases or no data

26 February: In the ongoing pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), more than 110 million confirmed cases, including 2.5 million deaths, have been documented globally since the outbreak began in December 2019. WHO

18 February: Seven asymptomatic cases of avian influenza A subtype H5N8, the first documented H5N8 cases in humans, are reported in Astrakhan Oblast, Russia, after more than 100,0000 hens died on a poultry farm in December. WHO

14 February: Seven cases of Ebola virus disease are reported in Gouécké, south-east Guinea. WHO

7 February: A case of Ebola virus disease is detected in North Kivu Province of the Democratic Republic of the Congo. WHO

4 February: An outbreak of Rift Valley fever is ongoing in Kenya, with 32 human cases, including 11 deaths, since the outbreak started in November. WHO

21 November: The US Food and Drug Administration (FDA) gives emergency-use authorisation to casirivimab/imdevimab, a combination monoclonal antibody (mAb) therapy for non-hospitalised people twelve years and over with mild-to-moderate COVID-19, after granting emergency-use authorisation to the single mAb bamlanivimab earlier in the month. FDA 1, 2

18 November: The outbreak of Ebola virus disease in Équateur Province, Democratic Republic of the Congo, which started in June, has been declared over; a total of 130 cases were recorded, with 55 deaths. UN

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Martinus Beijerinck in his laboratory in 1921
Martinus Beijerinck in his laboratory in 1921

The history of virology is usually considered to begin in the late 19th century, when the first evidence for the existence of viruses came from experiments using filters with pores small enough to retain bacteria. Dmitry Ivanovsky showed in 1892 that sap from a diseased tobacco plant remained infectious despite having been filtered; this agent, later known as tobacco mosaic virus, was the first virus to be demonstrated. In 1898, Friedrich Loeffler and Paul Frosch showed that foot-and-mouth, an animal disease, was caused by a filterable agent. That year, Martinus Beijerinck (pictured) called the filtered infectious substance a "virus" – often considered to mark the beginning of virology.

Bacteriophages, viruses that infect bacteria, were characterised by Frederick Twort and Félix d'Herelle in the early 20th century. In 1926, Thomas Milton Rivers defined viruses as obligate parasites. Viruses were demonstrated to be particles, rather than a fluid, by Wendell Meredith Stanley, and the invention of the electron microscope in 1931 allowed them to be visualised.

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Map showing Ebola virus disease cases in Guinea, Liberia and Sierra Leone in December 2014

The West African Ebola epidemic was the most widespread outbreak of the disease to date. Beginning in Meliandou in southern Guinea in December 2013, it spread to adjacent Liberia and Sierra Leone, affecting the cities of Conakry and Monrovia, with minor outbreaks in Mali and Nigeria. Cases reached a peak in October 2014 and the epidemic was under control by late 2015, although occasional cases continued to occur into April 2016. Ring vaccination with the then-experimental vaccine rVSV-ZEBOV was trialled in Guinea.

More than 28,000 suspected cases were reported with more than 11,000 deaths; the case fatality rate was around 40% overall and around 58% in hospitalised patients. Early in the epidemic nearly 10% of the dead were healthcare workers. The outbreak left about 17,000 survivors, many of whom reported long-lasting post-recovery symptoms. Extreme poverty, dysfunctional healthcare systems, distrust of government after years of armed conflict, local burial customs of washing the body, the unprecedented spread of Ebola to densely populated cities, and the delay in response of several months all contributed to the failure to control the epidemic.

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Recommended articles

Viruses & Subviral agents: bat virome • elephant endotheliotropic herpesvirus • HIV • introduction to viruses • Playa de Oro virus • poliovirus • prion • rotavirus • virus

Diseases: colony collapse disorder • common cold • croup • dengue fever • gastroenteritis • Guillain–Barré syndrome • hepatitis B • hepatitis C • hepatitis E • herpes simplex • HIV/AIDS • influenza • meningitis • myxomatosis • polio • pneumonia • shingles • smallpox

Epidemiology & Interventions: 2007 Bernard Matthews H5N1 outbreak • Coalition for Epidemic Preparedness Innovations • Disease X • 2009 flu pandemic • HIV/AIDS in Malawi • polio vaccine • Spanish flu • West African Ebola virus epidemic

Virus–Host interactions: antibody • host • immune system • parasitism • RNA interference

Methodology: metagenomics

Social & Media: And the Band Played On • Contagion • "Flu Season" • Frank's Cock • Race Against Time: Searching for Hope in AIDS-Ravaged Africa • social history of viruses • "Steve Burdick" • "The Time Is Now" • "What Lies Below"

People: Brownie Mary • Macfarlane Burnet • Bobbi Campbell • Aniru Conteh • people with hepatitis C • HIV-positive people • Bette Korber • Henrietta Lacks • Linda Laubenstein • Barbara McClintock • poliomyelitis survivors • Joseph Sonnabend • Eli Todd • Ryan White

Selected virus

X-ray crystallographic structure of the Norwalk virus capsid
X-ray crystallographic structure of the Norwalk virus capsid

Noroviruses are a genus of non-enveloped, single-stranded RNA viruses in the family Caliciviridae. The positive-sense RNA genome is approximately 7500 nucleotides long. Known noroviruses fall into five different genogroups (GI–GV); three groups infect humans, the other two mice, and cattle and other bovines. All are considered strains of a single species, Norwalk virus.

Noroviruses are extremely contagious, with fewer than 20 virus particles being infectious. They are transmitted directly from person to person and indirectly via contaminated water and food. After infection, the virus replicates in the small intestine, causing acute gastroenteritis, which develops 12–48 hours after exposure and lasts for 24–72 hours. The characteristic symptoms include nausea, forceful vomiting, watery diarrhoea and abdominal pain. Infection is usually self-limiting and rarely severe. Noroviruses cause 18% of acute gastroenteritis episodes in humans, with around 685 million cases and 200,000 deaths every year, mainly in very young, elderly or immunosuppressed people. No vaccine is available. Hand washing with soap and water is effective in reducing transmission.

Did you know?

White House Rose Garden ceremony on 26 September 2020, after which multiple participants tested positive for SARS-CoV-2

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Walter Reed

Walter Reed (13 September 1851 – 22 November 1902) was an American physician in the U.S. Army medical corps who is known for his research on the epidemiology of yellow fever, at a time when viruses had only just been discovered.

Reed started to study yellow fever in the USA in the 1890s, showing that walking through swampy woods at night was associated with the disease, while drinking water from the Potomac River was not. In 1900, he led an army commission under the direction of George Miller Sternberg to investigate yellow fever in Cuba, where the disease was endemic. Building on Carlos Finlay's work suggesting that yellow fever was transmitted by a particular species of mosquito acting as a vector, Reed and co-workers confirmed Finlay's results, and also disproved the popular idea that the disease was transmitted by contaminated objects, such as clothing or bedding. The experiments involved the deliberate infection of human volunteers, several of whom died of yellow fever, and Reed pioneered the concept of medical consent.

In this month

Painting depicting Jenner inoculating Phipps by Ernest Board (c. 1910)

May 1955: First issue of Virology; first English-language journal dedicated to virology

4 May 1984: HTLV-III, later HIV, identified as the cause of AIDS by Robert Gallo and coworkers

5 May 1939: First electron micrographs of tobacco mosaic virus taken by Helmut Ruska and coworkers

5 May 1983: Structure of influenza neuraminidase solved by Jose Varghese, Graeme Laver and Peter Colman

8 May 1980: WHO announced formally the global eradication of smallpox

11 May 1978: SV40 sequenced by Walter Fiers and coworkers

12 May 1972: Gene for bacteriophage MS2 coat protein is sequenced by Walter Fiers and coworkers, the first gene to be completely sequenced

13 May 2011: Boceprevir approved for the treatment of chronic hepatitis C virus (HCV) infection, the first direct-acting antiviral for HCV

14 May 1796: Edward Jenner inoculated James Phipps (pictured) with cowpox

15/16 May 1969: Death of Robert Rayford, the earliest confirmed case of AIDS outside Africa

18 May 1998: First World AIDS Vaccine Day

20 May 1983: Isolation of the retrovirus LAV, later HIV, by Luc Montagnier, Françoise Barré-Sinoussi and coworkers

23 May 2011: Telaprevir approved for the treatment of chronic HCV infection

25 May 2011: WHO declared rinderpest eradicated

31 May 1937: First results in humans from the 17D vaccine for yellow fever published by Max Theiler and Hugh H. Smith

Selected intervention

The MMR vaccine and autism fraud refers to the false claim that the combined vaccine for measles, mumps and rubella (MMR) might be associated with colitis and autism spectrum disorders. Multiple large epidemiological studies have since found no link between the vaccine and autism. The notion originated in a fraudulent research paper by Andrew Wakefield and co-authors, published in the prestigious medical journal The Lancet in 1998. Sunday Times journalist Brian Deer's investigations revealed that Wakefield had manipulated evidence and had multiple undeclared conflicts of interest. The paper was retracted in 2010, when the Lancet's editor-in-chief Richard Horton characterised it as "utterly false". Wakefield was found guilty of serious professional misconduct by the General Medical Council, and struck off the UK's Medical Register. The claims in Wakefield's article were widely reported in the press, resulting in a sharp drop in vaccination uptake in the UK and Ireland. A greatly increased incidence of measles and mumps followed, leading to deaths and serious permanent injuries.

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