Piperocaine is a local anesthetic drug developed in the 1920s and used as its hydrochloride salt for infiltration and nerve blocks.

Synthesis

Synthesis:[1] Patent:[2]

Alkylation between 3-chloropropyl benzoate [942-95-0] (1) and Pipicoline [109-05-7] (2) provides piperocaine (3).

See also

References

  1. ^ McElvain, S. M. (1927). "PIPERIDINE DERIVATIVES IV. SUBSTITUTED PIPERIDINE-ALKYL BENZOATES AND PARA-AMINOBENZOATES". Journal of the American Chemical Society 49 (11): 2835–2840. doi:10.1021/ja01410a030.
  2. ^ Samuel M Mcelvain, U.S. patent 1,784,903 (1930).

Further reading


  1. ^ Costich, Emmett R. (1950-02-01). "A Preliminary Study of the Efficiency of Piperocaine Hydrochloride as a Local Anesthetic in Dental Surgery". The Journal of the American Dental Association. 40 (2): 163–169. doi:10.14219/jada.archive.1950.0022. ISSN 0002-8177. PMID 15402120.