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by | Mar 16, 2018 | Hosta

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In enzymology, a peptidyl-glutaminase (EC 3.5.1.43) is an enzyme that catalyzes the chemical reaction

alpha-N-peptidyl-L-glutamine + H2O alpha-N-peptidyl-L-glutamate + NH3

Thus, the two substrates of this enzyme are alpha-N-peptidyl-L-glutamine and H2O, whereas its two products are alpha-N-peptidyl-L-glutamate and NH3.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is peptidyl-L-glutamine amidohydrolase. Other names in common use include peptidoglutaminase I, peptideglutaminase, and peptidoglutaminase.

References

  • Kikuchi M, Hayashida H, Nakano E, Sakaguchi K (1971). "Peptidoglutaminase. Enzymes for selective deamidation of gamma-amide of peptide-bound glutamine". Biochemistry. 10 (7): 1222–9. doi:10.1021/bi00783a019. PMID 4928623.


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