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Patient zero, or the index case, is the first documented patient in a disease epidemic within a population.

Patient zero may also refer to:

Gaëtan Dugas (1952–1984), once considered to be the initial source of AIDS in North America, and the origin of the term "patient zero"
Patient Zero (audio drama), 2009, based on the television series Doctor Who
Patient Zero (film), a 2018 fantasy-horror film
"Patient Zero" (The Outer Limits), a 2001 television episode
Patient Zero: A Joe Ledger Novel, 2009, by Jonathan Maberry
"Patient Zero", a 2000 short story by Tananarive Due
Patient Zero, a demoscene production by Farbrausch
Patient 0, an album by American deathcore band Enterprise Earth (together with the title track "Patient Zero")
"Patient Zero", a song by Hammerfall from the album Infected
"Patient Zero", a song by Aimee Mann from the album Mental Illness
Patient Zero, a campaign in the 2016 video game Hitman

See also