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Chemical compound
PPADS (pyridoxalphosphate-6-azophenyl-2',4'-disulfonic acid) is a selective purinergic P2X antagonist.[2] It is able to block contractions of rabbit vas deferens induced by ATP or α,β,methylene-ATP. It appears to be relatively selective for P2X receptors, having no appreciable activity at α1 adrenergic, muscarinic M2 and M3, histamine H1, and adenosine A1 receptors.[3]
References
- ^ PPADS tetrasodium salt, Santa Cruz Biotechnology
- ^ Ziganshin, AU (December 1993). "PPADS selectively antagonizes P2X-purinoceptor-mediated responses in the rabbit urinary bladder". British Journal of Pharmacology. 110 (4): 1491–95. doi:10.1111/j.1476-5381.1993.tb13990.x. PMC 2175839. PMID 8306091.
- ^ Lambrecht, G. (1992). "PPADS, a novel functionally selective antagonist of P2 purinoreceptor mediated responses". European Journal of Pharmacology. 217 (2–3): 217–19. doi:10.1016/0014-2999(92)90877-7. PMID 1330591.
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