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PIF1 5'-to-3' DNA helicase is a protein that in humans is encoded by the PIF1 gene. [5]
Function
This gene encodes a DNA-dependent adenosine triphosphate (ATP)-metabolizing enzyme that functions as a 5' to 3' DNA helicase. The encoded protein can resolve G-quadruplex structures and RNA-DNA hybrids at the ends of chromosomes. It also prevents telomere elongation by inhibiting the actions of telomerase. Alternative splicing and the use of alternative start codons results in multiple isoforms that are differentially localized to either the mitochondria or the nucleus. [provided by RefSeq, Nov 2013].
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000140451 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041064 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: PIF1 5'-to-3' DNA helicase". Retrieved 2018-05-17.
Further reading
- Zhang DH, Zhou B, Huang Y, Xu LX, Zhou JQ (2006). "The human Pif1 helicase, a potential Escherichia coli RecD homologue, inhibits telomerase activity". Nucleic Acids Res. 34 (5): 1393–404. doi:10.1093/nar/gkl029. PMC 1390689. PMID 16522649.
- Mateyak MK, Zakian VA (December 2006). "Human PIF helicase is cell cycle regulated and associates with telomerase". Cell Cycle. 5 (23): 2796–804. doi:10.4161/cc.5.23.3524. PMID 17172855.
- Futami K, Shimamoto A, Furuichi Y (September 2007). "Mitochondrial and nuclear localization of human Pif1 helicase". Biol. Pharm. Bull. 30 (9): 1685–92. doi:10.1248/bpb.30.1685. PMID 17827721.
- Gu Y, Masuda Y, Kamiya K (November 2008). "Biochemical analysis of human PIF1 helicase and functions of its N-terminal domain". Nucleic Acids Res. 36 (19): 6295–308. doi:10.1093/nar/gkn609. PMC 2577353. PMID 18835853.
- George T, Wen Q, Griffiths R, Ganesh A, Meuth M, Sanders CM (October 2009). "Human Pif1 helicase unwinds synthetic DNA structures resembling stalled DNA replication forks". Nucleic Acids Res. 37 (19): 6491–502. doi:10.1093/nar/gkp671. PMC 2770657. PMID 19700773.
- Sanders CM (August 2010). "Human Pif1 helicase is a G-quadruplex DNA-binding protein with G-quadruplex DNA-unwinding activity". Biochem. J. 430 (1): 119–28. doi:10.1042/BJ20100612. PMID 20524933.
- Gagou ME, Ganesh A, Thompson R, Phear G, Sanders C, Meuth M (July 2011). "Suppression of apoptosis by PIF1 helicase in human tumor cells". Cancer Res. 71 (14): 4998–5008. doi:10.1158/0008-5472.CAN-10-4404. PMID 21616935.
- Chisholm KM, Aubert SD, Freese KP, Zakian VA, King MC, Welcsh PL (2012). "A genomewide screen for suppressors of Alu-mediated rearrangements reveals a role for PIF1". PLOS ONE. 7 (2): e30748. Bibcode:2012PLoSO...730748C. doi:10.1371/journal.pone.0030748. PMC 3276492. PMID 22347400.
- Ramanagoudr-Bhojappa R, Chib S, Byrd AK, Aarattuthodiyil S, Pandey M, Patel SS, Raney KD (May 2013). "Yeast Pif1 helicase exhibits a one-base-pair stepping mechanism for unwinding duplex DNA". J. Biol. Chem. 288 (22): 16185–95. doi:10.1074/jbc.M113.470013. PMC 3668774. PMID 23596008.
External links
- Overview of all the structural information available in the PDB for UniProt: Q9H611 (ATP-dependent DNA helicase PIF1) at the PDBe-KB.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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