Oxetorone (INNTooltip International Nonproprietary Name), as oxetorone fumarate (USANTooltip United States Adopted Name) (brand names Nocertone, Oxedix), is a serotonin antagonist, antihistamine, and alpha blocker used as an antimigraine drug.[1][2][3][4] Association with hyperprolactinemia has been described[5] and antidopaminergic actions are also suspected.[6]

References

  1. ^ Ganellin CR, Triggle DJ (21 November 1996). Dictionary of Pharmacological Agents. CRC Press. pp. 1493–. ISBN 978-0-412-46630-4.
  2. ^ William Andrew Publishing (22 October 2013). Pharmaceutical Manufacturing Encyclopedia (3rd ed.). Elsevier. pp. 2935–. ISBN 978-0-8155-1856-3.
  3. ^ van Boxtel CJ, Santoso B, Edwards IR (6 August 2008). Drug Benefits and Risks: International Textbook of Clinical Pharmacology (Revised 2nd ed.). IOS Press. pp. 699–. ISBN 978-1-60750-345-3.
  4. ^ Massiou H (2000). "[Prophylactic treatments of migraine]". Revue Neurologique (in French). 156 (Suppl 4): 4S79–86. PMID 11139754.
  5. ^ Pradalier A (December 1996). "Hyperprolactinaemia and depression induced by oxetorone". Cephalalgia. 16 (8): 560–1. doi:10.1046/j.1468-2982.1996.1608560.x. PMID 8980859. S2CID 43533753.
  6. ^ Deguigne M, Bruneau C, Touré A, Turcant A, Le Roux G (February 2017). "New evidence for oxetorone toxicity". Clin Toxicol (Phila). 55 (2): 142–146. doi:10.1080/15563650.2016.1267358. PMID 27967233. S2CID 2137489.