OTU deubiquitinase 5 is a protein that in humans is encoded by the OTUD5 gene. [5]
Function
This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described.
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000068308 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031154 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: OTU deubiquitinase 5". Retrieved 2017-03-25.
Further reading
- Kayagaki N, Phung Q, Chan S, Chaudhari R, Quan C, O'Rourke KM, Eby M, Pietras E, Cheng G, Bazan JF, Zhang Z, Arnott D, Dixit VM (2007). "DUBA: a deubiquitinase that regulates type I interferon production". Science. 318 (5856): 1628–32. Bibcode:2007Sci...318.1628K. doi:10.1126/science.1145918. PMID 17991829. S2CID 46585990.
- Huang OW, Ma X, Yin J, Flinders J, Maurer T, Kayagaki N, Phung Q, Bosanac I, Arnott D, Dixit VM, Hymowitz SG, Starovasnik MA, Cochran AG (2012). "Phosphorylation-dependent activity of the deubiquitinase DUBA". Nat. Struct. Mol. Biol. 19 (2): 171–5. doi:10.1038/nsmb.2206. PMID 22245969. S2CID 33600627.
- Luo J, Lu Z, Lu X, Chen L, Cao J, Zhang S, Ling Y, Zhou X (2013). "OTUD5 regulates p53 stability by deubiquitinating p53". PLOS ONE. 8 (10): e77682. Bibcode:2013PLoSO...877682L. doi:10.1371/journal.pone.0077682. PMC 3797110. PMID 24143256.
External links
- Overview of all the structural information available in the PDB for UniProt: Q96G74 (Human OTU domain-containing protein 5) at the PDBe-KB.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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