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by | Mar 16, 2018 | Hosta

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Tetrahydropapaveroline (norlaudanosoline) is a benzyltetrahydroisoquinoline alkaloid.[1]

It can be formed in trace amounts in the brain by a condensation reaction of dopamine and dopaldehyde (a metabolite of dopamine).[1][2]

It inhibits dopamine uptake within the cerebral cortex.[3]

References

  1. ^ a b Richter, Derek (14 October 2016). Addiction and Brain Damage. Routledge. p. 24. ISBN 978-1-315-45403-0.
  2. ^ RD Myers; CL Melchior (29 April 1977). "Alcohol drinking: abnormal intake caused by tetrahydropapaveroline in brain". Science. 196 (4289): 554–556. Bibcode:1977Sci...196..554M. doi:10.1126/science.557839. PMID 557839.
  3. ^ Okada, T.; Shimada, S.; Sato, K.; Kotake, Y.; Kawai, H.; Ohta, S.; Tohyama, M.; Nishimura, T. (January 1998). "Tetrahydropapaveroline and its derivatives inhibit dopamine uptake through dopamine transporter expressed in HEK293 cells". Neuroscience Research. 30 (1): 87–90. doi:10.1016/s0168-0102(97)00121-1. ISSN 0168-0102. PMID 9572583.
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