There are three known mammalian tachykinin receptors termed NK1, NK2 and NK3. All are members of the 7 transmembrane G-protein coupled receptor family and induce the activation of phospholipase C, producing inositol triphosphate (so called Gq-coupled).

Inhibitors of NK-1, known as NK-1 receptor antagonists, can be used as antiemetic agents, such as the drug aprepitant.[1]

Binding

The genes and receptor ligands are as follows:[2]

Receptor Gene Preferred ligand
NK1 TACR1 substance P
NK2 TACR2 neurokinin A
NK3 TACR3 neurokinin B

(Hökfelt et al., 2001; Page, 2004; Pennefather et al., 2004; Maggi, 2000)

See also

References

  1. ^ "Aprepitant". NICE. Retrieved 2020-05-10.
  2. ^ Maggi CA (September 1995). "The mammalian tachykinin receptors". General Pharmacology. 26 (5): 911–44. doi:10.1016/0306-3623(94)00292-U. PMID 7557266.

External links