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NMP-7 is a drug which acts as both a non-selective agonist of the CB₁ and CB₂ cannabinoid receptors, and also as a blocker of T-type calcium channels, the target of anticonvulsant drugs such as ethosuximide. NMP-7 has an agonist EC₅₀ of 96.9nM at CB₁ and 10.5nM at CB₂, and an IC₅₀ of 1.84μM for blocking Cav3.2 T-type calcium channels. In animal studies it produces potent analgesic effects in a variety of different tests.^[1]

References

^ You H, Gadotti VM, Petrov RR, Zamponi GW, Diaz P (November 2011). "Functional characterization and analgesic effects of mixed cannabinoid receptor/T-type channel ligands". Molecular Pain. 7: 1744-8069–7-89. doi:10.1186/1744-8069-7-89. PMC 3250956. PMID 22093952.

[pmid22093952-1] You H, Gadotti VM, Petrov RR, Zamponi GW, Diaz P (November 2011). "Functional characterization and analgesic effects of mixed cannabinoid receptor/T-type channel ligands". Molecular Pain. 7: 1744-8069–7-89. doi:10.1186/1744-8069-7-89. PMC 3250956. PMID 22093952.

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See also

References

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