Mazaticol (Pentona) is an anticholinergic used as an antiparkinsonian agent in Japan.

The compound was known as PG-501 is first mentioned in Japanese studies in the early 1970s, noting "PG-501 was found to have pronounced anti-acetylcholine, anti-tremorine-induced tremor, anti-physostigmine-induced death, anti-haloperidol-induced parkinsonism and anti EEG arousal activities."[1][2]

References

  1. ^ Nose T, Kojima M, Ishida R, Shintomi K, Kowa Y (July 1971). "[Pharmacological properties of 6,6,9-trimethyl-9-azabicyclo (3,3,1)non-3 beta-yl-alpha, alpha-di(2-thienyl) glycolate hydrochloride monohydrate (PG-501), a new anti-parkinsonian agent]". Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica (in Japanese). 67 (4): 387–405. doi:10.1254/fpj.67.387. PMID 5000167.
  2. ^ Kosaka K (1971). "パ ー キ ン ソ ン病 に対 す るPG-501の 使 用 経 験/The Beneficial Effect of PG-501 on Parkinsonism". Rinsho Yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics. 2 (3): 230–235. doi:10.3999/jscpt.2.230. Retrieved December 18, 2023.

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