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Lou may refer to:
Personal name
- Lou (given name), a list of people and fictional characters
- Lou (German singer)
- Lou (French singer)
- Lou (surname 娄), the 229th most common surname in China
- Lou (surname 楼), the 269th most common surname in China
Arts and entertainment
- Lou (2010 film), a 2010 Australian film starring John Hurt
- Lou (2017 film), a Pixar short film
- Lou (2022 film), a Netflix crime thriller
- Lou!, a French series of comic books created by Julien Neel
- Lord of Ultima, a browser-based MMORTS game developed by EA
Other uses
- Lyon Olympique Universitaire, a rugby union team playing in the Top14 competition of France
- Bowman Field (airport) (IATA airport code LOU), an airport in Louisville, Kentucky, USA
- Lou Island of Papua New Guinea
- Lou language (Austronesian) of Lou Island
- Lou language (Torricelli)
- Letter of understanding, a formal text that sums up the terms and understanding of a contract
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