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Chemical compound
Lavoltidine (INN,[1] USAN, BAN; previously known as loxtidine, code name AH-23,844) is a highly potent and selective H2 receptor antagonist which was under development by Glaxo Wellcome (now GlaxoSmithKline)[2] as a treatment for gastroesophageal reflux disease but was discontinued due to the discovery that it produced gastric carcinoid tumors in rodents.[3][4]
See also
- H2 receptor antagonist
- Sufotidine (analogous sequence in which a sulfonyl group replaces the hydroxyl group)
References
- ^ "International Nonproprietary Names for Pharmaceutical Substances. Recommended International Nonproprietary Names (Rec. INN): List 30" (PDF). WHO Drug Information. 4 (3). World Health Organization: 7. 1990. Retrieved 12 January 2016.
- ^ "Drug Profile: Lavoltidine". AdisInsight. Springer International Publishing AG. Retrieved 12 January 2016.
- ^ Washington N (1991). Antacids and anti-reflux agents. Boca Raton: CRC Press. ISBN 0-8493-5444-7.
- ^ Dictionary of organic compounds. London: Chapman & Hall. 1996. ISBN 0-412-54090-8.
H2 antagonists ("-tidine") | |
---|---|
Prostaglandins (E)/ analogues ("-prost-") | |
Proton-pump inhibitors ("-prazole") | |
Potassium-competitive acid blockers ("-prazan") | |
Others | |
Combinations | |
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