LY-456219 is a potent and selective serotonin 5-HT1D receptor antagonist which has been used in research to study the function of presynaptic 5-HT1D autoreceptors. LY-456219 lacks significant affinity for the 5-HT1B, α1 adrenergic, and dopamine D2 receptors. [1][2]

References

  1. ^ Pullar IA, Boot JR, Broadmore RJ, Eyre TA, Cooper J, Sanger GJ, et al. (June 2004). "The role of the 5-HT1D receptor as a presynaptic autoreceptor in the guinea pig". European Journal of Pharmacology. 493 (1–3): 85–93. doi:10.1016/j.ejphar.2004.04.029. PMID 15189767.
  2. ^ Timms GH, Boot JR, Broadmore RJ, Carney SL, Cooper J, Findlay JD, et al. (May 2004). "SAR development of a selective 5-HT1D antagonist/serotonin reuptake inhibitor lead using rapid parallel synthesis". Bioorganic & Medicinal Chemistry Letters. 14 (10): 2469–2472. doi:10.1016/j.bmcl.2004.03.003. PMID 15109634.