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John Bryson (born 1943) is an American businessman and 37th United States Secretary of Commerce.

John Bryson may also refer to:

• John Bryson (mayor) (fl. c. 1889), American politician, 19th mayor of Los Angeles, California
• John Bryson (author) (1935–2022), Australian author and former lawyer
• John Bryson (Canadian politician) (1849–1896), Canadian lumberman, farmer, and politician from Quebec
• John Bryson (RAF officer) (1913?–1940), Canadian fighter pilot

See also

• John Bryson Chane (born 1944), bishop of Washington