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James A. Lake (born 1941) is an American evolutionary biologist.
Other people named James Lake include:
- James Andrew Trehane Lake (1840–1876), lawyer, businessman and parliamentarian in South Australia
- James Lake of the Lake baronets
- Jimmy Lake (born 1976), American football coach
James Lake may also refer to:
- James Lake (Arkansas), a reservoir in Fulton County, Arkansas
- James Lake (Ontario), a lake in Northeastern Ontario, Canada
- Northland Pyrite Mine (also known as James Lake Mine), a mine at the James Lake in Ontario
- Lake James (Indiana), a lake in northeastern Indiana, United States
- Lake James, a reservoir in North Carolina, United States
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