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by | Mar 16, 2018 | Hosta

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Isovanillin is a phenolic aldehyde, an organic compound and isomer of vanillin.[2] It is a selective inhibitor of aldehyde oxidase. It is not a substrate of that enzyme, and is metabolized by aldehyde dehydrogenase into isovanillic acid, which could make it a candidate drug for use in alcohol aversion therapy.[3] Isovanillin can be used as a precursor in the chemical total synthesis of morphine.[4][5] The proposed metabolism of isovanillin (and vanillin) in rat has been described in literature,[6] and is part of the WikiPathways[7] machine readable pathway collection.

See also

References

  1. ^ "Isovanillin". The PubChem Project. National Center for Biotechnology Information.
  2. ^ "isovanillin - Compound Summary (CID 12127)".
  3. ^ Georgios Panoutsopoulos; Christine Beedham (2005). "Enzymatic Oxidation of Vanillin, Isovanillin and Protocatechuic Aldehyde with Freshly Prepared Guinea Pig Liver Slices". Cell Physiol Biochem. 15 (1–4): 89–98. arXiv:quant-ph/0403227. doi:10.1159/000083641. PMID 15665519. S2CID 17057295.
  4. ^ Uchida, Kenji; Yokoshima, Satoshi; Kan, Toshiyuki; Fukuyama, Tohru (2006). "Total Synthesis of (±)-Morphine". Organic Letters. 8 (23): 5311–5313. doi:10.1021/ol062112m. PMID 17078705.
  5. ^ Uchida, Kenji; Yokoshima, Satoshi; Kan, Toshiyuki; Fukuyama, Tohru (2009). "Total Synthesis of (±)-Morphine". Heterocycles. 77 (2): 1219–1234. doi:10.1021/ol062112m. PMID 17078705. Retrieved 27 December 2013.
  6. ^ Strand, L. P.; Scheline, R. R. (January 1975). "The metabolism of vanillin and isovanillin in the rat". Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 5 (1): 49–63. doi:10.3109/00498257509056093. ISSN 0049-8254. PMID 1154798.
  7. ^ "Vanillin and isovanillin metabolism". WikiPathways. 2019-10-31.


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