Idalopirdine (INN) (code names Lu AE58054,) is a potent and selective 5-HT6 receptor antagonist under development by Lundbeck as an augmentation therapy for the treatment of cognitive deficits associated with Alzheimer's disease and schizophrenia.[1][2] As of October 2013 it is in phase III clinical trials.[2]

A phase III trial of two different daily doses of Lu AE58054 on top of 10 mg of donepezil for mild-to-moderate Alzheimer's failed to meet its primary endpoint with either dose.[3] Two further phase III trials failed too, the company confirmed in early 2017.[3]

See also

References

  1. ^ "U.S. Development Programs". Lundbeck.
  2. ^ a b "Search of: Lu AE58054 - List Results". ClinicalTrials.gov. National Library of Medicine, U.S. Department of Health and Human Services.
  3. ^ a b Taylor NP (23 September 2016). "PhIII Alzheimer's flop takes chunk out of Lundbeck, hits Axovant with aftershocks".

External links