How Can We Help?
Hemoglobin subunit zeta is a protein that in humans is encoded by the HBZ gene.[5][6]
Zeta-globin is an alpha-like hemoglobin. The zeta-globin polypeptide is synthesized in the yolk sac of the early embryo, while alpha-globin is produced throughout fetal and adult life. The zeta-globin gene is a member of the human alpha-globin gene cluster that includes five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta1 - 3'.[6]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000130656 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000055609 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Higgs DR, Vickers MA, Wilkie AO, Pretorius IM, Jarman AP, Weatherall DJ (April 1989). "A review of the molecular genetics of the human alpha-globin gene cluster". Blood. 73 (5): 1081–104. doi:10.1182/blood.V73.5.1081.1081. PMID 2649166.
- ^ a b "Entrez Gene: HBZ hemoglobin, zeta".
Further reading
- Giardina B, Messana I, Scatena R, Castagnola M (1995). "The multiple functions of hemoglobin". Critical Reviews in Biochemistry and Molecular Biology. 30 (3): 165–96. doi:10.3109/10409239509085142. PMID 7555018.
- Proudfoot NJ, Brownlee GG (September 1976). "3' non-coding region sequences in eukaryotic messenger RNA". Nature. 263 (5574): 211–4. Bibcode:1976Natur.263..211P. doi:10.1038/263211a0. PMID 822353. S2CID 4211839.
- Fougerousse F, Meloni R, Roudaut C, Beckmann JS (March 1992). "Dinucleotide repeat polymorphism at the human hemoglobin alpha-1 pseudo-gene (HBAP1)". Nucleic Acids Research. 20 (5): 1165. doi:10.1093/nar/20.5.1165. PMC 312136. PMID 1549498.
- Hess J, Perez-Stable C, Wu GJ, Weir B, Tinoco I, Shen CK (July 1985). "End-to-end transcription of an Alu family repeat. A new type of polymerase-III-dependent terminator and its evolutionary implication". Journal of Molecular Biology. 184 (1): 7–21. doi:10.1016/0022-2836(85)90039-7. PMID 2411938.
- Marotta CA, Forget BG, Weissman SM, Verma IM, McCaffrey RP, Baltimore D (June 1974). "Nucleotide sequences of human globin messenger RNA". Proceedings of the National Academy of Sciences of the United States of America. 71 (6): 2300–4. Bibcode:1974PNAS...71.2300M. doi:10.1073/pnas.71.6.2300. PMC 388440. PMID 4135409.
- Perez-Stable C, Ayres TM, Shen CK (September 1984). "Distinctive sequence organization and functional programming of an Alu repeat promoter". Proceedings of the National Academy of Sciences of the United States of America. 81 (17): 5291–5. Bibcode:1984PNAS...81.5291P. doi:10.1073/pnas.81.17.5291. PMC 391689. PMID 6089189.
- Clegg JB, Gagnon J (October 1981). "Structure of the zeta chain of human embryonic hemoglobin". Proceedings of the National Academy of Sciences of the United States of America. 78 (10): 6076–80. Bibcode:1981PNAS...78.6076C. doi:10.1073/pnas.78.10.6076. PMC 348980. PMID 6171809.
- Aschauer H, Schäfer W, Sanguansermsri T, Braunitzer G (December 1981). "[Human embryonic haemoglobins. Ac-Ser-Leu-Thr-is the N-terminal sequence of the zeta-chains (author's transl)]". Hoppe-Seyler's Zeitschrift für Physiologische Chemie. 362 (12): 1657–9. PMID 6172357.
- Aschauer H, Sanguansermsri T, Braunitzer G (August 1981). "[Human embryonic haemoglobins. The primary structure of the zeta chains (author's transl)]". Hoppe-Seyler's Zeitschrift für Physiologische Chemie. 362 (8): 1159–62. PMID 6179844.
- Proudfoot NJ, Gil A, Maniatis T (December 1982). "The structure of the human zeta-globin gene and a closely linked, nearly identical pseudogene". Cell. 31 (3 Pt 2): 553–63. doi:10.1016/0092-8674(82)90311-7. PMID 6297773. S2CID 36907055.
- Goodbourn SE, Higgs DR, Clegg JB, Weatherall DJ (August 1983). "Molecular basis of length polymorphism in the human zeta-globin gene complex". Proceedings of the National Academy of Sciences of the United States of America. 80 (16): 5022–6. Bibcode:1983PNAS...80.5022G. doi:10.1073/pnas.80.16.5022. PMC 384180. PMID 6308667.
- Cohen-Solal MM, Authier B, deRiel JK, Murnane MJ, Forget BG (1983). "Cloning and nucleotide sequence analysis of human embryonic zeta-globin cDNA". DNA. 1 (4): 355–63. doi:10.1089/dna.1982.1.355. PMID 6963223.
- Orkin SH, Michelson A (July 1980). "Partial deletion of the alpha-globin structural gene in human alpha-thalassaemia". Nature. 286 (5772): 538–40. Bibcode:1980Natur.286..538O. doi:10.1038/286538a0. PMID 7402334. S2CID 4251647.
- Flint J, Thomas K, Micklem G, Raynham H, Clark K, Doggett NA, King A, Higgs DR (March 1997). "The relationship between chromosome structure and function at a human telomeric region". Nature Genetics. 15 (3): 252–7. doi:10.1038/ng0397-252. PMID 9054936. S2CID 20630444.
- Luo HY, Liang XL, Frye C, Wonio M, Hankins GD, Chui DH, Alter BP (July 1999). "Embryonic hemoglobins are expressed in definitive cells". Blood. 94 (1): 359–61. doi:10.1182/blood.V94.1.359.413a29_359_361. PMID 10381533.
- Daniels RJ, Peden JF, Lloyd C, Horsley SW, Clark K, Tufarelli C, Kearney L, Buckle VJ, Doggett NA, Flint J, Higgs DR (February 2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Human Molecular Genetics. 10 (4): 339–52. doi:10.1093/hmg/10.4.339. PMID 11157797.
- Lau ET, Kwok YK, Chui DH, Wong HS, Luo HY, Tang MH (July 2001). "Embryonic and fetal globins are expressed in adult erythroid progenitor cells and in erythroid cell cultures". Prenatal Diagnosis. 21 (7): 529–39. doi:10.1002/pd.81. PMID 11494285. S2CID 11841129.
PDB gallery | |
|---|---|
|
Recent Comments