Haloprogesterone, sold under the brand name Prohalone, is a progestin medication which was previously marketed by Ayerst but is now no longer available.[1][2][3]
Chemistry
Haloprogesterone, also known as 6α-fluoro-17α-bromoprogesterone or as 6α-fluoro-17α-bromopregn-4-ene-3,20-dione, is a synthetic pregnane steroid and a halogenated derivative of progesterone.[1] It is specifically a derivative of 17α-bromoprogesterone and is similar structurally to medrogestone (6-dehydro-6,17α-dimethylprogesterone), medroxyprogesterone acetate (6α-methyl-17α-acetoxyprogesterone), and various other progestins derived from progesterone.[1]
Synthesis
Chemical syntheses of haloprogesterone have been published.[4]
History
Haloprogesterone was synthesized in 1960 and was introduced for medical use by 1961.[1][5][6]
Society and culture
Generic names
Haloprogesterone is the generic name of the drug and its INNTooltip International Nonproprietary Name and USANTooltip United States Adopted Name.[1][3]
Brand names
Haloprogesterone was marketed under the brand name Prohalone.[1]
References
- ^ a b c d e f Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 620–. ISBN 978-1-4757-2085-3.
- ^ American Pharmaceutical Association (1976). APhA drug names: an index of drug names. American Pharmaceutical Association. ISBN 9780917330094.
- ^ a b United States Adopted Names (USAN). United States Pharmacopeial Convention. 1968. p. 715.
- ^ Die Gestagene. Springer-Verlag. 27 November 2013. pp. 9–10. ISBN 978-3-642-99941-3.
- ^ Official Gazette of the United States Patent Office. The Office. 1961. p. 74.
- ^ The Journal of New Drugs. 1962. p. 127.
PRTooltip Progesterone receptor |
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mPRTooltip Membrane progesterone receptor (PAQRTooltip Progestin and adipoQ receptor) |
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