Globoidnan A is a lignan found in Eucalyptus globoidea, a tree native to Australia.

The molecule has been found to weakly inhibit the action of HIV integrase (IC50 = 0.64 μM) in vitro.[1] HIV integrase is an enzyme which is responsible for the introduction of HIV viral DNA into a host's cellular DNA. It is not known that globoidnan A inhibits the action of other retroviral integrases.

References

  1. ^ Ovenden SP, Yu J, Wan SS, et al. (2004). "Globoidnan A: a lignan from Eucalyptus globoidea inhibits HIV integrase". Phytochemistry. 65 (24): 3255–59. doi:10.1016/j.phytochem.2004.10.006. PMID 15561191.