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U-130 may refer to one of the following German submarines:

• SM U-130, a Type U 127 submarine laid down during the First World War but unfinished at the end of the war; broken up incomplete 1919–20
  • During the First World War, Germany also used this submarine with a similar name:
    • SM UB-130, a Type UB III submarine launched in 1918 and that served in the First World War until surrendered on 26 November 1918; used for French underwater explosion tests; broken up at Toulon in July 1921
• German submarine U-130 (1941), a Type IXC submarine that served in the Second World War until it was sunk on 12 March 1943