Fenpiverinium is an anticholinergic and antispasmodic compound;[1] it is marketed as a combination drug with pitofenone hydrochloride and either nimesulide or metamizole in Eastern Europe and India to treat smooth muscle spasms and pain.[2]

The combination with metamizole was removed from the market in Lithuania for safety reasons in 2000[3] and a boxed warning against use by children and adolescents was added in Serbia in 2005.[4] In 2016 India banned marketing of the combination with nimesulide along with 344 other combination drugs;[5][6] the order was overturned in December and appealed by the Government in January 2017.[7]

References

  1. ^ "Proposed INNs List 26" (PDF). WHO Chronicle. 25 (9). 1971.. "Recommended INNs List 12" (PDF). WHO Chronicle. 26 (10). 1973.
  2. ^ Vardanyan R (2017). Piperidine-Based Drug Discovery. Elsevier. ISBN 9780128134283.
  3. ^ Consolidated List of Products - Whose Consumption and/or Sale Have Been Banned, Withdrawn, Severely Restricted or Not Approved by Governments, Twelfth Issue. WHO. 2005. p. 305. Archived from the original on November 8, 2014.
  4. ^ Consolidated List of Products Whose Consumption and/or Sale Have Been Banned, Withdrawn, Severely Restricted or not Approved by Governments, Fourteenth Issue. WHO. 2009. p. 35.[dead link]
  5. ^ "Health ministry bans 344 fixed dose combination drugs". The Times of India. March 14, 2016.
  6. ^ "Gazette of India D. L.-33004/99. PART II—Section 3—Sub-section (ii)" (PDF). Government of India. March 10, 2016. Archived from the original (PDF) on 2018-08-26. Retrieved 2017-06-22.
  7. ^ "Govt moves SC to enforce ban on 344 Fixed Dose Combination drugs". The Times of India. January 31, 2017.