Hosta

FERM and PDZ domain containing 2 is a protein that in humans is encoded by the FRMPD2 gene. ^[5]

Function

This gene encodes a peripheral membrane protein and is located in a region of chromosome 10q that contains a segmental duplication. This copy of the gene is full-length and is in the telomeric duplicated region. Two other more centromerically proximal copies of the gene are partial and may represent pseudogenes. This full-length gene appears to function in the establishment and maintenance of cell polarization. The protein is recruited to cell-cell junctions in an E-cadherin-dependent manner, and is selectively localized at the basolateral membrane in polarized epithelial cells. Alternative splicing results in multiple transcript variants.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000170324 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000108841 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: FERM and PDZ domain containing 2". Retrieved 2017-09-05.

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Stenzel N, Fetzer CP, Heumann R, Erdmann KS (2009). "PDZ-domain-directed basolateral targeting of the peripheral membrane protein FRMPD2 in epithelial cells". J. Cell Sci. 122 (Pt 18): 3374–84. doi:10.1242/jcs.046854. PMID 19706687.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.