Etymemazine is an antipsychotic, antihistamine and anticholinergic drug of the phenothiazine chemical class, structurally related to cyamemazine and methotrimeprazine.[1]

Synthesis

Etymemazine can be synthesized by SN2 alkylation of 2-ethylphenothiazine (1) with 1-dimethylamino-2-methyl-3-chloropropane (2) using sodamide as a base.[2][3]

Synthesis of etymemazine

References

  1. ^ Milne GW (2002). "Etymemazine". Drugs: Synonyms and Properties (2nd ed.). Aldershot, Hampshire, England: Ashgate. p. 3945. ISBN 978-0-566-08491-1.
  2. ^ GB 789703  (1958 to Rhone Poulenc Sa).
  3. ^ Robert Michel Jacob, et al. U.S. patent 2,837,518 (1956 to Rhone Poulenc Sa)