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Ets variant 5 (ETV5) (also named ERM transcription factor) is a transcription factor that in humans is encoded by the ETV5 gene.[5] It is generated in Sertoli cells, which are found in the testes and play a crucial role in spermatogenesis. Its ortholog has been linked to both obesity and bipolar disorder.[6]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000244405 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000013089 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Ets variant 5".
- ^ Williams MJ, Klockars A, Eriksson A, Voisin S, Dnyansagar R, Wiemerslage L, Kasagiannis A, Akram M, Kheder S, Ambrosi V, Hallqvist E, Fredriksson R, Schiöth HB (June 2016). "The Drosophila ETV5 Homologue Ets96B: Molecular Link between Obesity and Bipolar Disorder". PLOS Genetics. 12 (6): e1006104. doi:10.1371/journal.pgen.1006104. PMC 4900636. PMID 27280443.
Further reading
- T'sas F, Brenner C, Mauen S, Putmans P, Monté D, Van Lint C, Moser M, Baert JL, de Launoit Y (January 2005). "Expression of the Ets transcription factor Erm is regulated through a conventional PKC signaling pathway in the Molt4 lymphoblastic cell line". FEBS Letters. 579 (1): 66–70. doi:10.1016/j.febslet.2004.11.052. PMID 15620692. S2CID 25112599.
- Brandys MK, van Elburg AA, Loos RJ, Bauer F, Hendriks J, van der Schouw YT, Adan RA (March 2010). "Are recently identified genetic variants regulating BMI in the general population associated with anorexia nervosa?". American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics. 153B (2): 695–9. doi:10.1002/ajmg.b.31026. PMID 19746409. S2CID 45793585.
- Colas E, Muinelo-Romay L, Alonso-Alconada L, Llaurado M, Monge M, Barbazan J, Gonzalez M, Schoumacher M, Pedrola N, Ertekin T, Devis L, Ruiz A, Castellvi J, Doll A, Gil-Moreno A, Vazquez-Levin M, Lapyckyj L, Lopez-Lopez R, Robine S, Friederich E, Castro M, Reventos J, Vignjevic D, Abal M (November 2012). "ETV5 cooperates with LPP as a sensor of extracellular signals and promotes EMT in endometrial carcinomas". Oncogene. 31 (45): 4778–88. doi:10.1038/onc.2011.632. hdl:11336/22664. PMID 22266854.
- Wang X, Yeh S, Wu G, Hsu CL, Wang L, Chiang T, Yang Y, Guo Y, Chang C (November 2001). "Identification and characterization of a novel androgen receptor coregulator ARA267-alpha in prostate cancer cells". The Journal of Biological Chemistry. 276 (44): 40417–23. doi:10.1074/jbc.M104765200. PMID 11509567.
- Korz C, Pscherer A, Benner A, Mertens D, Schaffner C, Leupolt E, Döhner H, Stilgenbauer S, Lichter P (June 2002). "Evidence for distinct pathomechanisms in B-cell chronic lymphocytic leukemia and mantle cell lymphoma by quantitative expression analysis of cell cycle and apoptosis-associated genes". Blood. 99 (12): 4554–61. doi:10.1182/blood.V99.12.4554. PMID 12036888.
- Chotteau-Lelièvre A, Révillion F, Lhotellier V, Hornez L, Desbiens X, Cabaret V, de Launoit Y, Peyrat JP (November 2004). "Prognostic value of ERM gene expression in human primary breast cancers". Clinical Cancer Research. 10 (21): 7297–303. doi:10.1158/1078-0432.CCR-04-0593. PMID 15534105. S2CID 14271353.
- Planagumà J, Liljeström M, Alameda F, Bützow R, Virtanen I, Reventós J, Hukkanen M (January 2011). "Matrix metalloproteinase-2 and matrix metalloproteinase-9 codistribute with transcription factors RUNX1/AML1 and ETV5/ERM at the invasive front of endometrial and ovarian carcinoma". Human Pathology. 42 (1): 57–67. doi:10.1016/j.humpath.2010.01.025. PMID 20970160.
- Monge M, Colas E, Doll A, Gil-Moreno A, Castellvi J, Diaz B, Gonzalez M, Lopez-Lopez R, Xercavins J, Carreras R, Alameda F, Canals F, Gabrielli F, Reventos J, Abal M (August 2009). "Proteomic approach to ETV5 during endometrial carcinoma invasion reveals a link to oxidative stress". Carcinogenesis. 30 (8): 1288–97. doi:10.1093/carcin/bgp119. PMID 19443906.
- Ng MC, Tam CH, So WY, Ho JS, Chan AW, Lee HM, Wang Y, Lam VK, Chan JC, Ma RC (May 2010). "Implication of genetic variants near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese". The Journal of Clinical Endocrinology and Metabolism. 95 (5): 2418–25. doi:10.1210/jc.2009-2077. PMID 20215397.
External links
- ERM+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- ETV5+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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