Eptazocine (Sedapain) is an opioid analgesic which was introduced in Japan by Morishita in 1987.[1][2][3][4] It acts as a mixed κ-opioid receptor agonist and μ-opioid receptor antagonist.[4][5][6]

See also

References

  1. ^ Index nominum 2000: international drug directory. Taylor & Francis US. 2000. p. 396. ISBN 978-3-88763-075-1. Retrieved 29 November 2011.
  2. ^ American Chemical Society. Division of Medicinal Chemistry (1990). "Cumulative NCE Introduction index, 1983-189, by Indication". In Bristol JA (ed.). Annual Reports in Medicinal Chemistry. Academic Press. p. 381. ISBN 978-0-12-040525-1. Retrieved 29 November 2011.
  3. ^ Nabeshima T, Matsuno K, Kamei H, Kameyama T (May 1985). "The interaction of eptazocine, a novel analgesic, with opioid receptors". Research Communications in Chemical Pathology and Pharmacology. 48 (2): 173–181. PMID 2992058.
  4. ^ a b Nagase H, Fujii H (21 January 2011). "Synthesis of Novel Basic Skeletons Derived from Naltrexone". In Nagase H, Calderon SN (eds.). Chemistry of Opioids. Springer. p. 280. ISBN 978-3-642-18106-1. Retrieved 29 November 2011.
  5. ^ Tamura T, Ogawa J, Taniguchi T, Waki I (January 1990). "[Preferential action of eptazocine, a novel analgesic, with opioid receptors in isolated guinea pig ileum and mouse vas deferens preparations]". Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica (in Japanese). 95 (1): 41–46. doi:10.1254/fpj.95.1_41. PMID 2154395.
  6. ^ Morton IK, Hall JM (1999). Concise dictionary of pharmacological agents: properties and synonyms. Springer. p. 113. ISBN 978-0-7514-0499-9. Retrieved 29 November 2011.