Ecnoglutide (XW003) is a GLP-1 agonist being developed for the treatment of obesity and type 2 diabetes.[1][2][3] In preclinical trials, "Ecnoglutide showed a favorable potency, pharmacokinetic, and tolerability profile, as well as a simplified manufacturing process" compared to other GLP-1 agonists.[4]

References

  1. ^ Wang, Guang; Hu, Wei; Qin, Hong H.; Zheng, Qing; Ning, Jing; Mengying, Guo; Bu, Yue; Jones, Catherine; Fenaux, Martijn; Xu, Susan; Junaidi, Mohammed K. (20 June 2023). "756-P: A Phase 1c Evaluation of a Novel GLP-1 Analog Ecnoglutide (XW003) for Weight Loss in Adults with Overweight and Obesity". Diabetes. 72 (Supplement_1). doi:10.2337/db23-756-P. S2CID 259383725.
  2. ^ Guo, Wanjun; Xu, Zheng; Zou, Haixia; Li, Feng; Li, Yao; Feng, Jing; Zhu, Zhiyi; Zheng, Qing; Zhu, Rui; Wang, Bin; Li, Yan; Hao, Sujuan; Qin, Hong; Jones, Catherine L.; Adegbite, Eric; Telusca, Libnir; Fenaux, Martijn; Zhong, Weidong; Junaidi, Mohammed K.; Xu, Susan; Pan, Hai (September 2023). "Discovery of ecnoglutide – A novel, long-acting, cAMP-biased glucagon-like peptide-1 (GLP-1) analog". Molecular Metabolism. 75: 101762. doi:10.1016/j.molmet.2023.101762. PMC 10339203. PMID 37364710.
  3. ^ Zhu, Dalong; Qin, Hong H.; Zheng, Qing; Ning, Jing; Zhu, Zhiyi; Mengying, Guo; Bu, Yue; Jones, Catherine; Fenaux, Martijn; Xu, Susan; Junaidi, Mohammed K. (20 June 2023). "755-P: A Phase 2 Evaluation of a Novel GLP-1 Analog Ecnoglutide (XW003) for Glycemic Control in Adults with Type 2 Diabetes". Diabetes. 72 (Supplement_1). doi:10.2337/db23-755-P. S2CID 259446339.
  4. ^ Guo, Wanjun; Xu, Zheng; Zou, Haixia; Li, Feng; Li, Yao; Feng, Jing; Zhu, Zhiyi; Zheng, Qing; Zhu, Rui; Wang, Bin; Li, Yan; Hao, Sujuan; Qin, Hong; Jones, Catherine L.; Adegbite, Eric; Telusca, Libnir; Fenaux, Martijn; Zhong, Weidong; Junaidi, Mohammed K.; Xu, Susan; Pan, Hai (September 2023). "Discovery of ecnoglutide - A novel, long-acting, cAMP-biased glucagon-like peptide-1 (GLP-1) analog". Molecular Metabolism. 75: 101762. doi:10.1016/j.molmet.2023.101762. ISSN 2212-8778. PMC 10339203. PMID 37364710.