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Opioid analgesic drug
Dimethylaminopivalophenone[1][2] is an opioid analgesic with a potency ½ that of morphine.[citation needed] It was initially discovered by Russian scientists in 1954 and subsequently rediscovered in the US in 1969.[3] Its LD50 in mice is 83 mg/kg.[4] It has never been marketed commercially.[citation needed]
See also
References
- ^ Brewster JH, Eliel EL (2011). "Carbon-Carbon Alkylations with Amines and Ammonium Salts". Organic Reactions. 7 (3): 99–197. doi:10.1002/0471264180.or007.03. ISBN 9780471264187.
- ^ Kleinman EF (April 2011). "Dimethyl(methylene)ammonium Iodide". Encyclopedia of Reagents for Organic Synthesis. doi:10.1002/047084289X.rd346. ISBN 978-0471936237.
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ignored (help) - ^ Atwal MS, Bauer L, Dixit SN, Gearien JE, Megahy M, Morris R, Pokorny C (November 1969). "Analgetics. II. Relationship between structure and activity of some beta-amino ketones". Journal of Medicinal Chemistry. 12 (6): 994–7. doi:10.1021/jm00306a006. PMID 5351480.
- ^ "2,2-dimethyl-3-(dimethylamino)-Propiophenone". ChemIDplus. Retrieved 2 October 2015.
μ-opioid (MOR) |
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δ-opioid (DOR) |
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κ-opioid (KOR) |
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Nociceptin (NOP) |
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Others |
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