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Cytokine dependent hematopoietic cell linker is a protein that in humans is encoded by the CLNK gene. [5]
Function
MIST is a member of the SLP76 family of adaptors (see LCP2, MIM 601603; BLNK, MIM 604515). MIST plays a role in the regulation of immunoreceptor signaling, including PLC-gamma (PLCG1; MIM 172420)-mediated B cell antigen receptor (BCR) signaling and FC-epsilon R1 (see FCER1A, MIM 147140)-mediated mast cell degranulation (Cao et al., 1999 [PubMed 10562326]; Goitsuka et al., 2000, 2001 [PubMed 10744659] [PubMed 11463797]).
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000109684 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039315 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Cytokine dependent hematopoietic cell linker". Retrieved 2017-09-06.
Further reading
- Cronin S, Tomik B, Bradley DG, Slowik A, Hardiman O (2009). "Screening for replication of genome-wide SNP associations in sporadic ALS". Eur. J. Hum. Genet. 17 (2): 213–8. doi:10.1038/ejhg.2008.194. PMC 2986065. PMID 18987618.
- Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
- Jin TB, Ren Y, Shi X, Jiri M, He N, Feng T, Yuan D, Kang L (2015). "Genetic variations in the CLNK gene and ZNF518B gene are associated with gout in case-control sample sets". Rheumatol. Int. 35 (7): 1141–7. doi:10.1007/s00296-015-3215-3. PMID 25591661. S2CID 23426576.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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