Chromosome 6 open reading frame 203 is a protein that in humans is encoded by the C6orf203 gene. [5]
C6orf203 protein is reported to be localised to the mitochondria of eukaryotes and possess an evolutionarily conserved RNA-binding domain.[6][7]
One study propose C6orf203 to associate with mitochondrial RNA polymerase (POLRMT) and increase mitochondrial transcription to protect the cell from mitochondrial RNA loss during stress.[7] However, another study propose C6orf203 to associate with the mitoribosomal large subunit and regulate mitochondrial translation.[6]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000130349 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019797 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Chromosome 6 open reading frame 203". Retrieved 2018-05-11.
- ^ a b Gopalakrishna S, Pearce SF, Dinan AM, Schober FA, Cipullo M, Spåhr H, et al. (August 2019). "C6orf203 is an RNA-binding protein involved in mitochondrial protein synthesis". Nucleic Acids Research. 47 (17): 9386–9399. doi:10.1093/nar/gkz684. PMC 6755124. PMID 31396629.
- ^ a b Kotrys AV, Cysewski D, Czarnomska SD, Pietras Z, Borowski LS, Dziembowski A, Szczesny RJ (June 2019). "Quantitative proteomics revealed C6orf203/MTRES1 as a factor preventing stress-induced transcription deficiency in human mitochondria". Nucleic Acids Research. 47 (14): 7502–7517. doi:10.1093/nar/gkz542. PMC 6698753. PMID 31226201.
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