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The enzyme choloyl-CoA hydrolase (EC 3.1.2.27) catalyzes the reaction

choloyl-CoA + H₂O

\rightleftharpoons

cholate + CoA

This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name is choloyl-CoA hydrolase. Other names in common use include PTE-2 (ambiguous), choloyl-coenzyme A thioesterase, chenodeoxycholoyl-coenzyme A thioesterase, and peroxisomal acyl-CoA thioesterase 2.

References

Hunt MC, Solaas K, Kase BF, Alexson SE (2002). "Characterization of an acyl-coA thioesterase that functions as a major regulator of peroxisomal lipid metabolism". J. Biol. Chem. 277 (2): 1128–38. doi:10.1074/jbc.M106458200. PMID 11673457.
Solaas K, Sletta RJ, Soreide O, Kase BF (2000). "Presence of choloyl- and chenodeoxycholoyl-coenzyme A thioesterase activity in human liver". Scand. J. Clin. Lab. Invest. 60 (2): 91–102. doi:10.1080/00365510050184903. PMID 10817395.
Russell DW (2003). "The enzymes, regulation, and genetics of bile acid synthesis". Annu. Rev. Biochem. 72: 137–74. doi:10.1146/annurev.biochem.72.121801.161712. PMID 12543708.

Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

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References

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