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by | Mar 16, 2018 | Hosta

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Cefonicide (or cefonicid) is a cephalosporin antibiotic.[1]

It has a density of 1.92g/cm3.

Synthesis

Injectable semi-synthetic cephalosporin antibiotic related to cefamandole, q.v.

Cefonicid synthesis:[2][3][4]

Cefonicid is synthesized conveniently by nucleophilic displacement of the 3-acetoxy moiety of 1 with the appropriately substituted tetrazole thiole 2. The mandelic acid amide C-7 side chain is reminiscent of cefamandole.

See also

References

  1. ^ Saltiel E, Brogden RN (September 1986). "Cefonicid. A review of its antibacterial activity, pharmacological properties and therapeutic use". Drugs. 32 (3): 222–59. doi:10.2165/00003495-198632030-00002. PMID 3530703. S2CID 243051006.
  2. ^ DE 2611270, Berges, David Alan, "Cephalosporin-Derivate [Cephalosporin derivatives]", published 1976-09-30, assigned to SmithKline Corp. 
  3. ^ D. A. Berges, U.S. patent 4,048,311 (1977 to Smith Kline).
  4. ^ U.S. patent 4,093,723, U.S. patent 4,159,373 (1978, 1979 both to Smith Kline).
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