Centrosomal protein 170kDa, also known as CEP170, is a protein that in humans is encoded by the CEP170 gene.[5][6]
Function
The product of this gene is a component of the centrosome, a non-membraneous organelle that functions as the major microtubule organizing center in animal cells. During interphase, the encoded protein localizes to the sub-distal appendages of mature centrioles, which are microtubule-based structures thought to help organize centrosomes. During mitosis, the protein associates with spindle microtubules near the centrosomes. The protein interacts with the intraflagellar transport protein 81 (IFT81), the SH3-domain containing protein PRAX-1, and is phosphorylated by cyclin dependent kinase 1 (Cdk1) and polo-like kinase 1 (PLK1), and functions in maintaining microtubule organization, cell morphology and cilium stability.[5]
The human genome contains a putative transcribed pseudogene. Several alternatively spliced transcript variants of this gene have been found, but the full-length nature of some of these variants has not been determined.[5]
References
- ^ a b c ENSG00000276725 GRCh38: Ensembl release 89: ENSG00000143702, ENSG00000276725 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000057335 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b c "Entrez Gene: CEP170 centrosomal protein 170kDa".
- ^ Guarguaglini G, Duncan PI, Stierhof YD, Holmström T, Duensing S, Nigg EA (March 2005). "The forkhead-associated domain protein Cep170 interacts with Polo-like kinase 1 and serves as a marker for mature centrioles". Molecular Biology of the Cell. 16 (3): 1095–107. doi:10.1091/mbc.E04-10-0939. PMC 551476. PMID 15616186.
External links
- Human CEP170 genome location and CEP170 gene details page in the UCSC Genome Browser.
- PDBe-KB provides an overview of all the structure information available in the PDB for Human Centrosomal protein of 170 kDa (CEP170)
Further reading
- Andersen JS, Wilkinson CJ, Mayor T, et al. (2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature. 426 (6966): 570–4. Bibcode:2003Natur.426..570A. doi:10.1038/nature02166. PMID 14654843. S2CID 4427303.
- Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
- Guarguaglini G, Duncan PI, Stierhof YD, et al. (2005). "The forkhead-associated domain protein Cep170 interacts with Polo-like kinase 1 and serves as a marker for mature centrioles". Mol. Biol. Cell. 16 (3): 1095–107. doi:10.1091/mbc.E04-10-0939. PMC 551476. PMID 15616186.
- Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells". J. Proteome Res. 4 (4): 1339–46. doi:10.1021/pr050048h. PMID 16083285.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
- Lamla S (2009). Functional characterisation of the centrosomal protein Cep170. Dissertation, LMU Muenchen: Fakultät für Biologie (Text.PhDThesis). URN nbn:de:bvb:19-97838.
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