Bufuralol is a potent beta-adrenoceptor antagonist with partial agonist activity.[1] It is metabolized by CYP2D6.[2]

Most beta blockers are aryloxypropanolamine-based. In this rare exception, the benzofuran oxygen is part of a ring instead of derived from the epichlorohydrin precursor.

References

  1. ^ Pringle, TH; Francis, RJ; East, PB; Shanks, RG (1986). "Pharmacodynamic and pharmacokinetic studies on bufuralol in man". British Journal of Clinical Pharmacology. 22 (5): 527–34. doi:10.1111/j.1365-2125.1986.tb02931.x. PMC 1401192. PMID 2878678.
  2. ^ Flockhart DA (2007). "Drug Interactions: Cytochrome P450 Drug Interaction Table". Indiana University School of Medicine. Retrieved on July 2011