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by | Mar 16, 2018 | Hosta

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Brunfelsamidine is a poisonous pyrrolidine occurring in several species belonging to the Solanaceous (nightshade family) genus Brunfelsia, which has convulsant and neurotoxic effects.[1] It is a fairly common cause of poisoning among domestic animals such as cows and dogs that eat the plant. Symptoms are similar to poisoning from strychnine and can last from a few hours up to several days.[2] It is also a weak tryptase (type of serine protease) inhibitor[3] and found in Leptonychia pubescens[3]

References

  1. ^ Lloyd HA; et al. (1985). "Brunfelsamidine: a novel convulsant from the medicinal plant Brunfelsia grandiflora". Tetrahedron Letters. 26 (22): 2623–4. doi:10.1016/S0040-4039(00)98119-X.
  2. ^ Bonagura JD, Twedt DC. Kirk's Current Veterinary Therapy XIV. ISBN 978-0-7216-9497-9.
  3. ^ a b Yang LK, Ng SP, Flotow H, Yoganathan K, Daramola BO, Soejarto DD, Buss AD, Butler MS (November 2005). "Pyrrole carboxamidine tryptase inhibitors from Leptonychia pubescens". Planta Medica. 71 (11): 1071–2. doi:10.1055/s-2005-873111. PMID 16320213.


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