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In enzymology, a blasticidin-S deaminase (EC 3.5.4.23) is an enzyme that catalyzes the chemical reaction

blasticidin S + H₂O deaminohydroxyblasticidin S + NH₃

Thus, the two substrates of this enzyme are blasticidin S and H₂O, whereas its two products are deaminohydroxyblasticidin S and NH₃.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is blasticidin-S aminohydrolase.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1WN5 and 1WN6.

References

• Yamaguchi I, Shibata H, Seto H, Misato T (January 1975). "Isolation and purification of blasticidin S deaminase from Aspergillus terreus". J. Antibiot. 28 (1). Tokyo: 7–14. doi:10.7164/antibiotics.28.7. PMID 236272.