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Chemical compound
β-Neoendorphin is an endogenous opioid peptide with a nonapeptide structure and the amino acid sequence Tyr-Gly-Gly-Phe-Leu-Arg-Lys-Tyr-Pro (YGGFLRKYP).[1]
β-Neoendorphins (β-NEP) have the capability to stimulate wound healing by accelerating keratinocyte migration. This is achieved by β-NEP's activation of mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinases 1 and 2 (ERK 1 and ERK 2); along with the upregulation of matrix metalloproteinase 2 and 9 (MMP-2 and MMP-9). Wound healing by β-NEP results in migration without consequences on proliferation in human keratinocytes.[2]
See also
References
- ^ Minamino N.; Kangawa K.; Chino N. (1981). "β-Neo-endorphin, a new hypothalamic 'big' leu-enkephalin of porcine origin: Its purification and the complete amino acid sequence". Biochemical and Biophysical Research Communications. 99 (3): 864–870. doi:10.1016/0006-291X(81)91243-2. PMID 7247945.
- ^ Yang, Dong Joo; Moh, Sang Hyun; Choi, Yun-Hee; Kim, Ki Woo (2020-10-12). "β-Neoendorphin Enhances Wound Healing by Promoting Cell Migration in Keratinocyte". Molecules. 25 (20): 4640. doi:10.3390/molecules25204640. ISSN 1420-3049. PMC 7587199. PMID 33053781.
μ-opioid (MOR) |
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δ-opioid (DOR) |
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κ-opioid (KOR) |
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Nociceptin (NOP) |
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Others |
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